The aim of our dementia theme is to develop novel treatments through precision medicine. Our focus on young onset and familial dementias will provide key insights into pathophysiological drivers that accelerate or cause neurodegeneration; and allow analysis of participants in the absence of comorbidity and in at-risk populations, a therapeutic window for intervention before functional decline.
Our sub-themes are interdependent. The genetic studies sub-theme will use biomarkers to determine influence on progression and endophenotypes that will be modelled in induced pluripotent stem cells; the latter will assist identification of novel interventions tested in the clinical applications sub-theme using outputs from the biomarkers of change sub theme.
We will be funding research projects in the dementia theme and will be reporting on these in due course.
Infrastructure and organisation
Key partners for the dementia theme include:
Leonard Wolfson Experimental Neurology Centre: The Leonard Wolfson Experimental Neurology Centre is a dedicated, specialist centre for the conduct of first-in-human studies of novel therapies for the treatment of neurodegenerative diseases.
Dementia Research Centre: The UCL Dementia Research Centre is a hub for clinical research which focuses on identifying and understanding the disease processes that cause dementia, the factors that influence these disease processes, and how best to support people with dementia and their families. In addition, the DRC also provides a cognitive disorders clinic within the National Hospital for Neurology and Neurosurgery.
Dementia Research Institute: The National Institute is funded by the MRC, Alzheimer’s Society and Alzheimer’s Research UK. The BRC dementia theme will have a major role in translating the basic discovery pipeline into the clinic.
Patient and Public Involvement
The dementia theme has an active lay panel that meets bi-annually. The scope of the panel is to engage and involve patients and public with current and future research activities within the programme, including the appraisal of proposed work, and publicising activities.
If you are a researacher interested in finding out more, contact Dr Daniel Herron firstname.lastname@example.org
For patients and the public
We are always keen to link up lay people with opportunities to get actively involved in research. The dementia theme has an active lay panel that meets bi-annually. For information, contact Dr Daniel Herron email@example.com