Neurodegeneration in the spinal cord is an important factor affecting disability progression in patients with primary progressive multiple sclerosis (PPMS), according to research published in Brain.
Researchers led by BRC-supported Professor Olga Ciccarelli used advanced magnetic resonance imaging (MRI) techniques to study spinal cord integrity, as pathological abnormalities in the spinal cord have been associated with disability in patients with PPMS.
The researchers found structural damage of neurons, demyelination and chemical abnormalities in the cervical cord of early PPMS, as reflected by MRI measures, in the absence of extensive spinal cord atrophy.
The results suggest that early spinal neurodegeneration may underlie clinical impairment, and should be targeted in future clinical trials with neuroprotective drugs to prevent the development of progressive disability. Spinal cord abnormalities, investigated by MRI, could be used to predict clinical outcomes and treatment response in clinical trials in PPMS.
PPMS is characterised by a progressive worsening of neurologic functioning, including cognitive functions.
To read Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis click here.
