The Oral Health and Disease theme funds core staffing infrastructure dedicated to clinical trials in oral health conditions.
Our dedicated team ensures we are best placed to lead and manage clinical trials in this underserved but important area within our state-of-the-art facilities housed within the new UCLH Royal National ENT & Eastman Dental Hospitals.
Our strategic investment in clinical trial infrastructure is reflected in our recruitment figures to NIHR Portfolio studies, which are the highest nationally. Below is a list of studies that are currently open at UCLH.
|
Study Acronym |
Study Title |
Funder |
UCL PI |
|
|
Abnormal genes and proteins in oral inflammatory diseases |
|
Stefano Fedele |
|
ANTIC |
Advanced neuroimaging to study the central pain pathways in trigeminal neuralgia (tic douloureux) pre and post-microvascular decompression |
UCLH NIHR BRC |
Joanna Zakrewska |
|
CABRIO |
The Clinical And Biological effects of the use of probiotic VSL#3 in participants with oral lichen planus: a proof-of-concept study |
|
Andrew Smith |
|
DERMTREAT |
Phase 2b clinical trial of Rivelin® Clobetasol patch (Rivelin®-CLO) for oral lichen planus. |
|
Stefano Fedele |
|
|
Development of core outcomes for trigeminal neuralgias |
|
Joanna Zakrzewska |
|
DIHSCO |
Diabetes, Hypertension, and COVID Screening (DIHSCO): Diabetes, Hypertension and COVID Exposure Screening in Tertiary Care Dental Setting |
BHR Pharmaceuticals |
Francesco D’Aiuto |
|
DOMINO |
The development and validation of a medication-related osteonecrosis of the jaws-specific patient reported outcome measures |
NIHR |
Stefano Fedele |
|
IMAGO |
Innovative methods of periodontal soft tissue imaging in vivo. A STROBE-BASED CASE/CONTROL- STUDY. |
GSK |
Francesco D’Aiuto |
|
LASSO |
Local and Systemic Effects of Peri-implantitis and its Treatment (LASSO). A Randomised Controlled Clinical Trial |
Association of Dental Infection Control |
Francesco D’Aiuto |
|
LEGEND |
Electrical impedance spectroscopy on glove: Non-invasive diagnosis of oral cancer at a fingertip |
UCLH NIHR BRC |
Andreas Demosthenous Stefano Fedele |
|
LEONIDAS-1 |
Long-term effectiveness of a novel intra-oral electro-stimulator for the treatment of dry mouth in patients with Sjogren's syndrome: a feasibility study |
Versus Arthritis |
Stefano Fedele |
|
The LEONIDAS2 study |
Long-term Evaluation of the effectiveness Of a Novel Intra-oral electro-stimulator for the treatment of raDiotherapy-ASsociated dry mouth (The LEONIDAS-2 study) |
NIHR Research for Patient Benefit |
Stephen Porter |
|
MANTRA |
Mechanisms of Acute Inflammation following Periodontal Treatment |
Regedent |
Francesco D’Aiuto |
|
MEAN-IT |
Determination of minimal important difference and patient acceptable symptom state of patient reported outcome measures in immunologically mediated oral mucosal diseases |
|
Stefano Fedele |
|
NOVEL |
Novel Strategies for Vertical Ridge Augmentation (NOVEL): A feasibility Randomized Controlled Clinical Trial |
Geistlich, Investigator Initiated Grant |
Francesco D’Aiuto |
|
ODIN-Q |
Development of an Oral Epithelial Dysplasia Informational Needs Questionnaire |
|
Richeal Ni Riordain |
|
ORACLE |
Oral health, microbial burden and COVID-19 |
DermBiont inc |
Francesco D’Aiuto |
|
PERCIVAL |
Periodontitis, COVID-19 and Cerebrovascular Disease |
Eklund Foundation |
Francesco D’Aiuto |
|
PITSTOP |
PentoxIfylline and Tocopherol for the treatment of post radiotherapy fibrosis in head and neck cancer Patients: a feasibility study |
NIHR Research for Patient Benefit |
Stefano Fedele |
|
PTM |
Periodontal Treatment Model (PTM) |
Indonesian Ministry of Health |
Francesco D’Aiuto |
|
RAPTOR |
Repurposed drug combination Pentoxifylline, Tocopherol and Clodronate (PENTOCLO) in the treatment of osteoradionecrosis of the mandible |
|
Stefano Fedele |
|
REMIX |
Patient Reported Outcome Measures in Radiotherapy Induced Xerostomia – Which Instrument Should We Use?) |
Iraqi Cultural Bureau |
Stefano Fedele |
|
ROBUST |
Regeneration of Bone Tissue Using Periosteal-derived cells |
Rigenera HBW |
Francesco D’Aiuto |
|
SALRISE |
Salivary electro-stimulation for the treatment of dry mouth in patients with Sjogren's syndrome: a multicentre randomised sham-controlled double-blind study |
Versus Arthritis |
Stefano Fedele |
|
SAVER |
Sodium Valproate for Epigenetic Reprogramming in the Management of High-Risk Oral Epithelial Dysplasia |
University of Liverpool |
Stefano Fedele |
|
SCARF |
Efficacy and safety of Gold Collagen® liquid food supplements on vascular function: a pilot double blind randomized placebo controlled clinical trial |
Minerva Labs |
Francesco D’Aiuto |
|
SMART |
Naturally and synthetic smart composite biomaterials for tissue regeneration |
NIHR i4i, Schottlander Ltd and UCLH NIHR BRC |
Anne Young |
|
SMART (Vertebrae) |
Smart composites modification for vertebral Fracture Repair |
Royal Society Newton Fund |
Anne Young |
|
SURGE-1 |
A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia |
Biogen Idec Inc, Biogeny PLC |
Joanna Zakrzewska |
|
SS-INQ |
Defining the informational needs of patients with Sjögren’s Syndrome and development of a Sjögren’s Syndrome-specific Informational Needs Questionnaire |
|
Stefano Fedele |
|
STATUE |
Soft Tissue Augmentation Using Tissue Engineering |
Indonesian Ministry of Health |
Francesco D’Aiuto |
|
TOPIC |
Improving the Oral Health of Older People in Care Homes: a Feasibility Study |
NIHR |
George Tsakos |
|
|
Treatment of Periodontal Disease in Systemic Lupus Erytematosus. A Pilot Randomized Controlled Clinical Trial. |
Versus Arhrtitis |
Lucy Wedderbun, Coziana Ciurtin, Francesco D’Aiuto |
|
TRINCOS |
Rosetrees Trust |
Joanna Zakrzewska |
