Our university links provide the cardiovascular theme with a strong foundation in fundamental science, but we also work closely with patients and volunteers, including very large national longitudinal studies, international consortia and national health records data.
We also work closely with other BRC specialist themes because the heart and blood vessels influence the development and progress of diseases of many vital organs; and many disease processes such as inflammation and cancer spread.
Our work focuses on heart conditions where there is an unmet need including many inherited conditions, heart failure (including cardiac consequences of cancer and its treatment), and atrial fibrillation and other heart rhythm problems. We also work to understand mechanisms of blood vessel disease in the brain, such as stroke, aneurysm formation and haemorrhage, which may contribute to memory decline and dementia. Our work on blood vessels in the eye and lung aims to understand the mechanisms of, and develop new treatments for, diabetic eye disease, macular degeneration and pulmonary hypertension.
Advances in technology for imaging, the study of human physiology, blood protein and chemistry composition (proteomics and metabolomics) and the human genome means there has never been a better time to understand disease mechanisms, develop new diagnostic markers and new treatments.
Our cross- cutting supporting subthemes are:
- Cardiovascular ‘–omics’ and informatics
- Biomarker discovery for precision medicine
- Advanced phenotyping
Our disease-focused research subthemes are:
- Myocardial disorders
- Vascular mechanisms in disease
- Inherited and congenital cardiovascular disorders